Early cell fate decisions in the mouse embryo
نویسندگان
چکیده
منابع مشابه
Cell fate decisions and axis determination in the early mouse embryo.
The mouse embryo generates multiple cell lineages, as well as its future body axes in the early phase of its development. The early cell fate decisions lead to the generation of three lineages in the pre-implantation embryo: the epiblast, the primitive endoderm and the trophectoderm. Shortly after implantation, the anterior-posterior axis is firmly established. Recent studies have provided a be...
متن کاملEarly embryonic cell fate decisions in the mouse.
During development, initially totipotent cells of the embryo specialize to form discrete tissue lineages. The first lineages to form in the mouse are the extraembryonic tissues. Meanwhile, cells that do not become extraembryonic retain a pluripotent fate since they can give rise to all the germ layers of the fetus. Pluripotent stem cell lines have been derived from the fetal lineage at several ...
متن کاملThe chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo
The separation of embryonic from extra-embryonic tissues within the inner cell mass to generate the epiblast (EPI), which will form the new organism, from the primitive endoderm (PE), which will form the yolk sac, is a crucial developmental decision. Here, we identify a chromatin modifier, Satb1, with a distinct role in this decision. Satb1 is differentially expressed within 16-cell-stage embry...
متن کاملFate mapping the mouse embryo.
The use of clonal analysis to obtain a fate map of the epiblast of the mouse embryo and to investigate cell distribution during gastrulation and early neurulation is described in a personal reminiscence. A revised fate map of the epiblast at 6.5 days gestation is provided, and the development of 3-dimensional, quantitative image analysis techniques outlined.
متن کاملFollowing cell fate in the living mouse embryo.
It has been difficult to follow many of the dramatic changes in cell fate and cell migration during mouse development. This is because there has been no enduring marker that would allow cells to be recognised in the living embryo. We believe that we have overcome this problem by developing a novel form of green fluorescent protein, named MmGFP, that proves to be easily visible and non toxic to ...
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ژورنال
عنوان ژورنال: REPRODUCTION
سال: 2013
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-12-0381